It contains quality fish oil for the all-important DHA and EPA fatty acids. The fish oil used comes from fish that stores the fat in the body (not fish liver oil). The fish oil used is Reviact™ Multi Omega is menhaden fish oil, an omega-3 rich fish harvested in the federally regulated waters along the Atlantic and Gulf coasts. Reviact™ Multi Omega also includes alpha linolenic acid from vegetable fats such as flaxseed. DHA (Docosahexaenoic Acid) and EPA (Eicosapentaenoic Acid) are the most important anti-inflammatory fatty acids. They are also important building blocks for healthy cell membrane structure. The mechanism of action of omega-3 fatty acid is to inhibit the conversion of arachidonic acid (AA). AA is an omega-6 fatty acid producing prostaglandins, leukotrienes, and thromboxanes. These eicosanoids have predominantly vasoactive and proinflammatory effects. Inhibiting the conversion of AA to these eicosanoids is the principal action of most NSAIDs used to treat OA. Eicosanoids produced from EPA and DHA are not potent inflammatory mediators, in contrast to those produced from AA.

New research has focused on the health benefits of short-chain fructooligosaccharides (scFOS), which are low-calorie, non-digestible carbohydrates that can improve food taste and texture while aiding immunity, bone health and the growth and balance of important bacteria in the digestive track. A recent review in Acta Cirurgica Brasileira found that FOS can reduce cholesterol levels in animal studies. Introducing FOS into a calorie-restricted diet also helped these animals to reduce weight gain.

probiotics, it's a good idea to look for those which contain bacteria that has shown to be effective for treating allergy and allergic rhinitis. Lactobacillus GG and L. gasseri are believed to be two of the best probiotics for allergies, along with L. acidophilus and Bifidobacterium lactis.

Specific forms and doses of AG increased white blood cell, neutrophil and eosinophil concentrations. Arabinogalactan is a unique dietary fiber that affects the digestive physiology and immunological characteristics of dogs. It helps maintain proper gut flora and boosts the immune system. Promote the growth of probiotic bacteria such as Lactobacilli and bifidobacterial in the intestines, which are important for GI tract health. -Support proper immune system function. The benefits of arabinogalactan, once its fermented in the dog’s gut, is quite impressive: It goes to work in protecting the dog’s intestines against viruses and bacteria.

With its naturally occurring antihistamine properties it helps as a decongestant and with its anti-inflammatory properties eases itching. Within the turmeric spice lies a miraculous compound called ‘Curcumin’. This compound, found in several other plants, has been extensively researched. The reason It has been found to possess anti-inflammatory properties that can relieve swelling and pain as effectively as ibuprofen or aspirin. These medicinal properties are crucial in assisting us to care for our aging canines; Arthritis, the thinning of cartilage between bones and joints can cause excruciating pain. Turmeric helps relieve this pain in a natural way without worrying about toxic side-effects that can accompany pharmaceutical solutions. That way, they will be able to keep playing with you even as they grow older!

Atopic dermatitis affects 3-15% of the general dog population and it has been diagnosed by veterinarians up to 58% of dogs affected with skin disease. It is usually a life-long pathology which can be controlled, but it can be seldom cured. The present investigation describes a case study in which lactoferricin and verbascoside are part of a formulation to obtain a dermatological lotion for canine dermatitis treatment. During treatment period the total clinical score progressively decreased associated with an improvement in clinical signs. No adverse effects were reported in any of the treated dogs. The present research suggests that daily applications of tested emulsion are effective in reducing bacterial overgrowth and clinical signs in skin folds and atopic dermatitis.

Glutamine has several functions including the support of immunity, gastrointestinal integrity, insulin secretion, neurological activity, and muscle protein synthesis. Glutamine is often recommended for pets with chronic bowel disorders including inflammatory bowel disease and parvovirus enteritis, since it is the preferred fuel source of damaged intestinal epithelial cells. It Helps reduce muscle soreness by enhancing muscle recovery during sports events or exercise and Maintenance of Muscle Tissue. Glutamine is an energy source for intestinal and immune cells. It also helps maintain the barrier between the intestines and the rest of your body and aids with proper growth of intestinal cells.

Resveratrol (RV) is a natural non-flavonoid polyphenol and phytoalexin produced by several plants such as peanuts, grapes and berries. Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways. Administration of the polyphenol has a potential to slow down the development of CVD (cardiovascular disease) by influencing on certain risk factors such as development of diabetes or atherosclerosis. Resveratrol has been promoted to have many health benefits such as protecting the heart and circulatory system, lowering cholesterol, and protecting against clots which can cause heart attacks and stroke.

To understand the immunomodulatory effects of Lactobacillus acidophilus L-92 cells suggested from our previous study of in vivo anti-allergy and anti-virus effects, host immune responses in macrophage-like THP-1 cells after 4 h (the early phase) and 24 h (the late phase) of cocultivation with L-92 cells were investigated by transcriptome analysis. In the early phase of L-92 treatment, various transcription regulator genes, such as, NFkB1, NFkB2, JUN, HIVEP2 and RELB, and genes encoding chemokines and cytokines, such as CCL4, CXCL11, CCL3 and TNF, were upregulated. Increases in some Th1-type cytokines and chemokines have been observed in previous in vitro and in vivo studies with L-92 (1,2).
REFERENCES
1. Kanzato H, Fujiwara S, Ise W, Kaminogawa S, Sato R, Hachimura S. 2008. Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells by modulating dendritic cell function. Immunobiology 213: 399–408. [PubMed] [Google Scholar]
2. Torii A, Torii S, Fujiwara S, Tanaka H, Inagaki N, Nagai H. 2007. Lactobacillus acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol Int 56: 293–301. [PubMed] [Google Scholar]